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lumefantrine will minimize the extent or outcome of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of.rufinamide will reduce the extent or effect of diazepam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.Diazepam does not enhance or minimize hepatic enzyme action, and does n